|
photo by Nancy Steffens |
This
question draws forth images of children heading off to school each morning,
riding on their saber-tooth cats, pet moas stalking along behind, dodging
roaming mammoths along their way.
What is cloning, really?
Cloning is a
process that makes genetically identical copies of an organism. There is such a thing as natural cloning –
this occurs with some plants and single-cell organisms which copy themselves without
fertilization, and identical twins are also natural clones. As for artificial cloning, there are three
basic types – gene, therapeutic and reproductive.
Gene cloning
makes copies of genes or DNA, and therapeutic cloning makes stem cells for
creating new tissues. But here we’ll be
talking about reproductive cloning -- the method by which an animal can be
created from material cells, such as those from skin and hair.
The basic
process is this: an egg is taken from a living animal and the cell’s nucleus is
removed. To review, the nucleus is where
the DNA hangs out, which instructs the cell as to what to do with itself. Then a cell is taken from the animal to be
cloned, and its nucleus is removed and put into the host egg. This is done either by just sucking it out
with a syringe and inserting it into the egg, or by joining the two with an
electric pulse.
Now you have
a living animal’s egg containing a nucleus from another (could be dead)
animal. The egg is spurred into action
with electricity, and after it grows to embryo size in a lab, it is placed into
the womb of a related species.
There’s a
handy illustrated fact sheet about the process here.
Now you
could have a kitten growing in Cat C that came from the egg of Cat B and a skin
cell of Cat A. Or a saber-tooth baby
going for a ride in a lion. Or even a
Tasmanian tiger, the genes of which have been made to be produced in the fetus
of a mouse -- not that the mouse in this case carried a tiger to term, but it
illustrates that you don’t need to have the same kind of animal to recreate
age-old genes. Surrogate mothers for full-term,
fully-formed creatures should, however, be at least somewhat related to the
original species.
So thanks to
the existence of elephants, we could find a surrogate mother for a mammoth, and
recreating the passenger pigeon via a rock pigeon’s egg would be easy (as easy
as cloning is, that is.) But the lack of
availability of a suitable womb would postpone the de-extinction of some
species, notably the giant ground sloth, which will have to wait for an
artificial womb because its closest living relative – the 8-kg two-toed sloth –
would have a mighty hard time birthing a 1,000-kg ground sloth baby.
As for
animals that have no existing relatives, there is still hope. As recently as 2007, a method was found for
reverting adult cells into embryo-like stem cells, which could then be made to
produce any kind of tissue call. So finding
an egg to host is not necessarily necessary, but the technology still has a ways
to go before it becomes particularly efficient.
Does it work?
Most of the
time, actually, no. Cloning has a very
low success rate compared with good ol’ regular reproduction. The first animal successfully cloned from an
adult cell – the famous Dolly the sheep, born in 1996 – followed 276 failed
attempts.
While
cloning from adult cells of living creatures has gradually gotten more
successful, the overall baby production process is still way less efficient
than letting the animals reproduce naturally, not to mention that clones have a
higher propensity for health problems than non-clones.
So as far as,
say, producing livestock, cloning makes no sense. But in the case of extinct animals, it is the
only way.
So whose DNA do we actually have available
to clone right now?
Creatures
that died off more than a few tens of thousands of years ago are gone for good;
their DNA has broken down by now.
However, animals that have gone extinct during or after the last ice age
stand a chance if some of their tissue was preserved. Ice-age creatures have been found preserved
in -- no surprise -- ice, as well as tar pits, and animals that died more
recently have been collected by curators of museums and labs.
The San
Diego’s FrozenZoo has cells from over 1,000 different species, including critically
endangered species like the northern white rhino. Around the globe, cells are on hand that
could possibly be reborn into a number of extinct species, including the
recently extinct Tasmanian tiger and passenger pigeon, the giant moa, the Irish
elk, and yes, saber-tooth cats and mammoths.
Also in the
lineup for de-extinctable species are – ready for this? – Neanderthals. Recent evidence has suggested that those
beefy cave-dwellers were actually much more intelligent and articulate than
previously believed, and it turns out that they’re not so separate of a species
from us after all. In fact,
interbreeding certainly occurred, and still does, sort of – it so happens that
a lot of us have Neanderthal DNA in us right now! My own uncle recently got confirmation that
he’s 2% Neanderthal, so I guess I’m in the club. Does that explain why I lumber around so much
before I get coffee?
Has anyone brought an extinct species back?
Yes, indeed
– but sadly, not for long. In 2003,
scientists cloned a Pyrenean Ibex, the first to exist on Earth since the species’
presumed extinction in 1999. Unfortunately,
the youngster died soon after birth from a malformation in its lungs.
Still, hope
is in the air, and plans are ever afoot to clone lost creatures, especially the
iconic mammoth. Japan’s Dr. Akira
Iritani claims he will produce a mammoth by 2016…which is pretty optimistic, considering
the general failure rate and the fact that the critter will have to gestate for
a good year and a half at least.
It seemed like a good idea at the time
So should we
really be doing this?
When faced
with the question of whether the dinosaurs in the movie Jurassic Park should exist, Jeff Goldblum’s character Dr. Malcolm
says, “Your scientists were so preoccupied with
whether or not they could that they didn't stop to think if they should!”
There are
those who believe that we owe
resurrection to creatures that humans drove to extinction. This excerpt from a NationalGeographic article shows the stance nicely:
“If we’re talking
about species we drove extinct, then I think we have an obligation to try to do
this,” says Michael Archer, a paleontologist at the University of New South
Wales who has championed de-extinction for years. Some people protest that
reviving a species that no longer exists amounts to playing God. Archer scoffs
at the notion. “I think we played God when we exterminated these animals.”
There is
also the belief that we should carry on with cloning because, well, we
can. As Insung Hwang of the Sooam
Biotech Research Foundation says, “The thing that I always say is, if you don’t
try, how would you know that it’s impossible?”
Some reasons
to reconsider just up and cloning everything include concern about the survival
of the animals once they’re back on Earth.
For some species, their former habitat is greatly reduced or entirely unavailable. Alternately, some species whose habitat is
intact may pose a threat to the ecosystem that has established itself since the
animals’ departure, making the extinct species now an invasive one.
Others
believe that resources would be better spent focused on the preservation of
existing endangered species. Cash goes a
lot further in environmental preservation efforts than it does in the realm of
low-success-rate cloning. Proponents of
the focus-on-the-now crowd also see cloning as better used to preserve tissues
and attempt to clone living endangered animals before working on those that are
already extinct.
The
seven-year-old who brought up this question thinks that science should
certainly try to clone some extinct species, but cautions against reviving the
“dangerous” species of the past. “Wooly
mammoths could be stomping on and destroying everything…and saber-tooth tigers
would do damage to alive creatures.” I
can see some wisdom in that.
Truth, bro.
But really, pros and cons aside,
wouldn’t it just be neat to see some ice age megafauna cruising around in the
flesh? Hank Greely, a leading
bioethicist at Stanford University, agrees:
“What intrigues me is just that it’s
really cool,” Greely says. “A saber-toothed cat? It would be neat to see one of those.”
Especially if we could ride it to school.